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Cytogenetic, histopathologic, and immunologic studies of multifocal renal cell carcinoma
Author(s) -
Junker Kerstin,
Schlichter Andreas,
Junker Udo,
Knöfel Brigitte,
Kosmehl Hartwig,
Schubert Jörg,
Claussen Uwe
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970301)79:5<975::aid-cncr14>3.0.co;2-#
Subject(s) - medicine , pathology , renal cell carcinoma , carcinoma , renal carcinoma
BACKGROUND Multifocal tumor areas occurred in 12‐22% of patients with renal cell carcinoma. It is unknown whether these tumors have malignant potential and characterize a higher risk for metastases. The performance of nephron‐sparing surgery in patients with low grade or low stage tumors is controversial. METHODS Primary and secondary tumors were analyzed by conventional cytogenetics and fluorescence in situ hybridization. Production of interleukin (IL)‐6, IL‐10, IL‐11, and transforming growth factor (TGF)‐β1 were determined using standard enzyme‐linked immunosorbent assay and bioassays. RESULTS In 15.2% of the renal cell carcinoma cases evaluated, multifocal tumors were detected. Cytogenetics revealed a concordance of primary and secondary tumors in 9 of 14 cases (64%). In 11 of 12 multifocal tumors (94%), the same immunologic activity status was observed in both primary and secondary tumors. CONCLUSIONS Secondary tumors must be expected to have malignant potential similar to that of the primary tumors. This was underscored by the high concordance of cytogenetic, histopathologic, and immunologic data in this study. Cancer 1997; 79:975‐81. © 1997 American Cancer Society.