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Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging
Author(s) -
Yamamura Shigeki,
Sato Keiji,
Sugiura Hideshi,
Katagiri Hirohisa,
Ando Yoko,
Fukatsu Hiroshi,
Iwata Hisashi
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970115)79:2<255::aid-cncr8>3.0.co;2-j
Subject(s) - medicine , magnetic resonance imaging , edema , pathology , osteochondroma , bone marrow , chondroblastoma , chondrosarcoma , radiology
BACKGROUND Several reports have shown peritumoral edema accompanying primary bone tumors demonstrated by magnetic resonance imaging (MRI). However, the mechanism of this inflammatory reaction is still unclear. The authors postulated that the reaction was caused by some chemical mediators including prostanoids, because several investigators have observed that some types of bone tumors synthesize prostanoids. Therefore, the authors compared MRI findings and tumor prostaglandin (PG) levels. METHODS The subjects were 29 patients with primary bone tumor or tumor‐like conditions: chondroblastoma (n = 5); chondrosarcoma, including rare variants (n = 8); giant cell tumor (n = 6); osteochondroma (n = 5); osteoblastoma (n = 2); Ewing's sarcoma (n = 2); and eosinophilic granuloma (n = 1). T1‐ and T2‐weighted spin echo images were obtained in all but one patient before surgery. The tumor concentration of prostaglandin E 2 , 6‐keto‐PGF 1α , and thromboxane B 2 were measured by radioimmunoassay. RESULTS MRI distinctly showed bone marrow edema in 9 and soft tissue edema in 12 of the 28 patients examined. These findings were significantly correlated with the PG levels. Moreover, the PG levels were correlated with the histologic classifications ( P < 0.001). In particular, the chondroblastomas showed prominent concentrations of PGs compared with other cartilaginous tumors or giant cell tumors. CONCLUSIONS Although peritumoral edema accompanying benign and malignant bone tumors is not necessarily related to one single pathophysiologic mechanism, these results suggest that PG production was an important cause of the inflammatory reaction that was revealed by MRI. Recognition of this phenomenon is advantageous not only for strict diagnostic purposes but also for understanding the characteristic features of individual primary bone tumors. Cancer 1997; 79:255‐61. © 1997 American Cancer Society.