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High occurrence of primary malignant neoplasms in patients with adult T‐cell leukemia/lymphoma, their siblings, and their mothers
Author(s) -
Kozuru Mitsuo,
Uike Naokuni,
Muta Kouichirou,
Goto Tatsurou,
Suehiro Youko,
Nagano Mitsuyuki
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960901)78:5<1119::aid-cncr24>3.0.co;2-4
Subject(s) - medicine , malignant lymphoma , leukemia , lymphoma , primary (astronomy) , oncology , pathology , physics , astronomy
BACKGROUND Attempts were made to clarify the correlation between human T‐cell leukemia/lymphoma virus (HTLV)‐1 infection and malignant oncogenicity other than adult T‐cell leukemia/lymphoma (ATL) in a case–control study. METHODS The occurrence of primary malignant neoplasms (MN) in 110 ATL patients, their parents, and 430 siblings was compared with HTLV‐1 seronegative non‐Hodgkin's lymphoma (NHL) patients, their parents, and 867 siblings. The chi‐square test, odds ratio (OR), and 95% confidence intervals (CI) were used to determine the statistical significance of differences in the occurrence of the primary MN among ATL patients, HTLV‐1 seronegative NHL patients, their siblings, and their parents. RESULTS The occurrence of primary MN in the ATL patients was higher than the occurrence in HTLV‐1 seronegative NHL patients ( P = 0.0036; OR = 2.91; 95% CI: 1.42, 6.02). In siblings of the ATL patients, there was a higher occurrence of primary MN than in siblings of the HTLV‐1 seronegative NHL patients ( P < 0.0001; OR = 3.35; 95% CI: 2.01, 5.58). In mothers of the ATL patients, there was a higher occurrence of primary MN than in mothers of the HTLV‐1 seronegative NHL patients ( P = 0.0063; OR = 2.55; 95% CI: 1.30, 5.00), but not in fathers ( P = 0.1602; OR = 1.68; 95% CI: 0.81, 3.47). CONCLUSIONS There is an increased risk of primary MN in ATL patients, their siblings, and their mothers. Cancer 1996;78:1119‐24.