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The effect of calcium and vitamin supplements on the incidence and recurrence of colorectal adenomatous polyps
Author(s) -
Neugut Alfred I.,
Horvath Karen,
Whelan Richard L.,
Terry Mary Beth,
Garbowski Gail C.,
Bertram Andrea,
Forde Kenneth A.,
Treat Michael R.,
Waye Jerome
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960815)78:4<723::aid-cncr5>3.0.co;2-f
Subject(s) - medicine , aspirin , colonoscopy , incidence (geometry) , vitamin , polypectomy , colorectal cancer , vitamin d and neurology , gastroenterology , calcium , adenoma , calcium supplementation , surgery , cancer , physics , optics
BACKGROUND Recent attention has focused on calcium and certain vitamins as potential protective agents against colorectal neoplasia. METHODS Two case‐control studies were conducted on patients who underwent colonoscopy between 1986 and 1988, comparing 297 patients with newly diagnosed adenomas with 505 controls (without current or prior history of neoplasia), and 198 patients with recurrent adenomas with 347 recurrent controls (with no current neoplasia, but with a history of polypectomy). Subjects were interviewed regarding their regular usage of supplementation with vitamins A, C, D, and E, or with calcium, multivitamins, or any vitamin supplements. RESULTS No consistent associations were observed with the use of any of these supplements. CONCLUSIONS More studies are necessary to confirm these findings. It may be necessary to develop other chemopreventive agents, such as aspirin, for colorectal neoplasia. Cancer 1996;78:723‐8.