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MIB‐1 staining index and peritumoral brain edema of meningiomas
Author(s) -
Ide Mitsunobu,
Jimbo Minoru,
Yamamoto Masaaki,
Umebara Yutaka,
Hagiwara Shinji,
Kubo Osami
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960701)78:1<133::aid-cncr19>3.0.co;2-0
Subject(s) - edema , medicine , immunostaining , meningioma , pathology , brain edema , magnetic resonance imaging , staining , immunohistochemistry , brain tumor , radiology
BACKGROUND Growth rates and tumor aggressiveness of meningiomas are thought to be closely related to brain edema development. However, histopathologic data alone are not consistently accurate predictors of the behavior and clinical course of a meningioma. METHODS The authors examined 57 histologically proven intracranial meningiomas to identify factors, including growth fractions determined by MIB‐1 immunostaining, that may influence the development of meningioma‐associated peritumoral brain edema. There were 54 benign, 2 atypical, and 1 anaplastic meningiomas. The MIB‐1 staining index (SI) percentage was defined as the number of MIB‐1‐positive cells divided by the total number of tumor cells in a 1.037‐square millimeter area on the slide. The extent of peritumoral brain edema was determined using preoperative magnetic resonance imaging. The extent of edema was classified as Grade 0, 1, or 2 (GR0, GR1, or GR2), in order of increasing severity. RESULTS The MIB‐1 SIs of the 57 cases ranged from 0.06–6.8% (median, 0.80%). There were 26 GR0, 20 GR1, and 11 GR2 edema cases. The MIB‐1 SI rose in order of increasing edema severity. There was a statistically significant correlation between the MIB‐1 SI and the extent of brain edema ( P < 0.0001), and also between the tumor size and the extent of brain edema ( P = 0.001). Meningothelial and atypical/anaplastic meningiomas were associated with peritumoral brain edema more often than any other subtype ( P < 0.005). CONCLUSIONS Growth fractions, as determined by MIB‐1 immunostaining, rise with increasing severity of peritumoral brain edema, indicating a close relationship between tumor aggressiveness and edema development. Cancer 1996;78:133‐43.