Premium
Prognostic factors for patients with localized primary malignant fibrous histiocytoma: A multicenter study of 216 patients with multivariate analysis
Author(s) -
Le Doussal Viviane,
Coindre JeanMichel,
Leroux Agnès,
Hacene Kamel,
Terrier Philippe,
Bui N'guyen Binh,
Bonichon Françoise,
Collin Françoise,
Mandard AnneMarie,
Contesso Geneviève
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960501)77:9<1823::aid-cncr10>3.0.co;2-1
Subject(s) - medicine , radiation therapy , confidence interval , multivariate analysis , relative risk , cancer , metastasis , stage (stratigraphy) , sarcoma , adverse effect , oncology , primary tumor , chemotherapy , surgery , pathology , paleontology , biology
BACKGROUND The purpose of this study was to determine the independent prognostic variables in a well documented subset of 216 patients with localized primary malignant fibrous histiocytomas (MFH). METHODS Between the years 1980 and 1989, 216 patients with localized, primary (International Union Against Cancer [UICC]/American Joint Committee on Cancer [AJCC] Stage I–IVA) MFH were evaluated and treated in 10 participating centers of the sarcoma group of the French Federation of Cancer Centers (FNCLCC). Clinicopathologic factors were collected retrospectively and entered into a cooperative database. Tissue slides of all cases were jointly reviewed microscopically by the pathology subcommittee. Surgical treatment was performed on all but 6 (3%) patients. One hundred ninety‐five patients (90%) were free of gross disease, with complete local control at the end of the initial treatment. The adjuvant treatment was radiotherapy in 78 patients (36%), chemotherapy in 19 patients (9%), and both in 61 patients (28%). RESULTS The median follow‐up was 3.5 years (range, 45 days to 12 years). Five‐year actuarial rates of disease specific (DSS), metastasis free (MFS), and local recurrence free (LRFS) survival were 70%, 63.3%, and 62.7%, respectively. Multivariate analyses showed that the adverse prognostic factors independently associated with decreased disease specific survival were UICC/AJC Stage III + IVA ( P < 0.00001; relative risk [RR], 3.27; 95% confidence interval [CI], 1.6–6.58), residual macroscopic disease following primary local therapy ( P = 0.00024; RR, 3.99; Cl, 2.04–7.82), deep tumor location ( P = 0.0045; RR, 3.37; Cl, 1.21–9.38), non‐myxoid histology ( P = 0.0056; RR, 9.28; Cl, 1.03–83.41), and age older than 50 years ( P = 0.037; RR, 2.19; Cl, 1.04–4.61). Two factors were significantly related to MFS in the patients with the poorest prognosis: histopathologic Grade 3 ( P < 0.0001, RR, 3.46; Cl, 2.02–5.91) and tumor size greater than 8 cm in largest dimension ( P = 0.0012; RR, 2.78; Cl, 1.36–3.66). With regard to LRFS, patients who did not undergo radiotherapy had reduced local control ( P = 0.0043; RR, 2.36; Cl, 1.46–3.83). CONCLUSIONS Resection of all macroscopic disease was independently associated with improved disease specific survival and adjuvant radiotherapy significantly decreased the local relapse risk. Histopathologic grade was the most important prognostic factor for DSS and MFS. Cancer 1996;77:1823‐30.