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What is the earliest malignant lesion in the esophagus?
Author(s) -
Kitamura Kaoru,
Kuwano Hiroyuki,
Yasuda Mitsuhiro,
Sonoda Kozo,
Sumiyoshi Kohei,
Tsutsui Shinichi,
Kitamura Masayuki,
Sugimachi Keizo
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960415)77:8<1614::aid-cncr29>3.0.co;2-1
Subject(s) - medicine , esophagus , dysplasia , esophageal cancer , lesion , cancer , endoscopic mucosal resection , carcinoma , esophageal disease , pathology , endoscopy , radiology
BACKGROUND The incidence of early esophageal cancer is definitely increasing due to recent advances in diagnostics. When we discuss early carcinoma of the esophagus, however, there is still controversy as to whether dysplasia is either benign or the earliest malignant lesion. METHODS Nineteen resected esophaguses with both cancer and dysplasia (including 19 cancers concomitant with 26 dysplastic lesions) were studied for expression of p53 protein. RESULTS Immunohistochemical overexpression of p53 protein in esophageal dysplasia is almost the same as that in cancer. CONCLUSIONS Esophageal dysplasia should be recognized as the earliest malignant lesion which already demonstrates cancerous features although it is not immediately critical. A routine endoscopic Lugol's solution test is very useful for both detection and following‐up of the early nests in the esophagus. These lesions are good candidates for endoscopic mucosal resection for the purpose of accurate diagnosis or curative treatment. Cancer 1996;77:1614‐9.