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Neuroendocrine differentiation is an independent prognostic factor in chemotherapy‐treated nonsmall cell lung carcinoma
Author(s) -
Schleusener Jeffrey T.,
Tazelaar Henry D.,
Jung Sinho,
Cha Stephen S.,
Cera Peter J.,
Myers Jeffrey L.,
Creagan Edward T.,
Goldberg Richard M.,
Marschke Robert F.
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960401)77:7<1284::aid-cncr9>3.0.co;2-i
Subject(s) - neuroendocrine differentiation , medicine , chromogranin a , synaptophysin , chemotherapy , pathology , etoposide , immunohistochemistry , lung cancer , oncology , large cell , carcinoma , tumor marker , stage (stratigraphy) , cancer , adenocarcinoma , prostate cancer , biology , paleontology
BACKGROUND Neuroendocrine differentiation can be identified in 10–30% of patients with nonsmall cell lung carcinoma (NSCLC) by immunohistochemical or electron microscopic techniques. However, its clinical significance is not well established. METHODS Tumors from 107 patients with Stage IIIA, IIIB, and IV NSCLC treated with cisplatin/etoposide with or without hydrazine in the North Central Cancer Treatment Group and Mayo Clinic protocols were analyzed immunohistochemically with antibodies to chromogranin A (CGA), Leu 7 (CD 57), and synaptophysin (SY). These results were compared with clinical outcomes. RESULTS Keratin AE1/AE3, used as a control, was positive in 99.1% of cases; 34.6% had positive staining for at least 1 neuroendocrine marker, and 11.3% had positive staining for 2 or more markers. CGA was positive in 4.7%, Leu 7 in 18.7%, and SY in 24.3% of cases. A significant increase in survival was seen in patients with tumors expressing any one neuroendocrine marker or any combination of neuroendocrine markers ( P ; cc 0.01). There was no correlation between the presence of neuroendocrine differentiation and either response to chemotherapy or time to disease progression ( P > 0.3), nor was there any correlation between chemotherapy response, time to progression, or survival with staining intensity or percent of cells positive per case. CONCLUSIONS Neuroendocrine differentiation may be of prognostic significance in patients with advanced stage NSCLC treated with chemotherapy. Cancer 1996;77:1284‐91.