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Surgical treatment of lung metastases: The European Organization for Research and Treatment of Cancer‐Soft Tissue and Bone Sarcoma Group study of 255 patients
Author(s) -
van Geel Albert N.,
Pastorino Ugo,
Jauch Karl W.,
Judson Ian R.,
van Coevorden Frits,
Buesa José M.,
Nielsen Ole S.,
Boudinet Alain,
Tursz Tomas,
Schmitz Paul I. M.
Publication year - 1996
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19960215)77:4<675::aid-cncr13>3.0.co;2-y
Subject(s) - medicine , soft tissue , sarcoma , chondrosarcoma , soft tissue sarcoma , surgery , cancer , lung cancer , bone sarcoma , alveolar soft part sarcoma , proportional hazards model , oncology , pathology
BACKGROUND Several reports have shown a prolonged survival after surgical treatment of pulmonary metastases from soft tissue sarcomas. However, it is still unclear which prognostic factors predict a favorable outcome. Series are not comparable and the data are conflicting. Therefore, a multi‐institutional study was undertaken to analyze prognostic factors in selecting patients for resection of pulmonary metastases from soft tissue sarcomas. METHODS This report is a retrospective study of the European Organization for Research and Treatment of Cancer‐Soft Tissue and Bone Sarcoma Group. Two hundred fifty‐five patients underwent complete resection of lung metastases from soft tissue sarcomas. Cases with chondrosarcoma and small round cell sarcomas like Ewing sarcoma were excluded. RESULTS The 3 year and 5 year overall postmetastasectomy survival rates were 54% and 38%, respectively. The disease free postmetastasectomy survival rates were 42% and 35%, respectively. Analysis of prognostic factors for a more favorable outcome revealed disease free intervals of 2.5 years or more, following a resection with microscopically free margins, age less than 40 years, and Grade I and II tumors. These prognostic factors have an independent influence on overall survival, using a multivariate Cox regression model. CONCLUSIONS Surgical excision of lung metastases from soft tissue sarcomas is well accepted and should be considered as a first line of treatment if preoperative evaluation indicates that complete clearance of the metastases is possible. Further investigation is needed before chemotherapy can be recommended as additional therapy. Cancer 1996; 77:675‐82.