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Do more complex organisms have a greater proportion of membrane proteins in their genomes?
Author(s) -
Stevens Timothy J.,
Arkin Isaiah T.
Publication year - 2000
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/(sici)1097-0134(20000601)39:4<417::aid-prot140>3.0.co;2-y
Subject(s) - genome , proteome , biology , archaea , computational biology , bacterial genome size , membrane protein , genetics , gene , evolutionary biology , membrane
One may speculate that higher organisms require a proportionately greater abundance of membrane proteins within their genomes in order to furnish the requirements of differentiated cell types, compartmentalization, and intercellular signalling. With the recent availability of several complete prokaryotic genome sequences and sufficient progress in many eukaryotic genome sequencing projects, we seek to test this hypothesis. Using optimized hydropathy analysis of proteins in several, diverse proteomes, we show that organisms of the three domains of life—Eukarya, Eubacteria, and Archaea—have similar proportions of α‐helical membrane proteins within their genomes and that these are matched by the complexity of the aqueous components. Proteins 2000;39:417–420. © 2000 Wiley‐Liss, Inc.