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Estimates of the loss of main‐chain conformational entropy of different residues on protein folding
Author(s) -
Pal Debnath,
Chakrabarti Pinak
Publication year - 1999
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/(sici)1097-0134(19990815)36:3<332::aid-prot7>3.0.co;2-h
Subject(s) - conformational entropy , chemistry , entropy (arrow of time) , protein folding , amino acid residue , side chain , polypeptide chain , crystallography , thermodynamics , amino acid , biochemistry , peptide sequence , physics , molecule , organic chemistry , gene , polymer
The average contribution of conformational entropy for individual amino acid residues towards the free energy of protein folding is not well understood. We have developed empirical scales for the loss of the main‐chain (torsion angles, ϕ and ψ) conformational entropy by taking its side‐chain into account. The analysis shows that the main‐chain component of the total conformational entropy loss for a residue is significant and reflects intrinsic characteristics associated with individual residues. The values have direct correlation with the hydrophobicity values and this has important bearing on the folding process. Proteins 1999;36:332–339. © 1999 Wiley‐Liss, Inc.