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Protein folds from pair interactions: A blind test in fold recognition
Author(s) -
Flöckner Hannes,
Domingues Francisco S.,
Sippl Manfred J.
Publication year - 1997
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/(sici)1097-0134(1997)1+<129::aid-prot17>3.0.co;2-q
Subject(s) - fold (higher order function) , computer science , programming language
We submitted nine predictions to CASP2 using our fold recognition program ProFIT. Two of these structures were still unsolved by the end of the experiment, six had a recognizable fold, and one fold was new. Four predictions of the six recognizable folds were correct. Two models were excellent in terms of alignment quality (T0031, T0004): in one the alignment was partially correct (T0014), and one fold was correctly identified (T0038). We discuss improvements of the program and analyze the prediction results. Proteins, Suppl. 1:129–133, 1997. © 1998 Wiley‐Liss, Inc.