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Cationic copolymers of α,β‐poly‐( N ‐2‐hydroxyethyl)‐ DL ‐aspartamide (PHEA) and α,β‐polyasparthylhydrazide (PAHy): synthesis and characterization
Author(s) -
Giammona Gaetano,
Cavallaro Gennara,
Pitarresi Giovanna,
Pedone Elisa
Publication year - 2000
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/(sici)1097-0126(200001)49:1<93::aid-pi299>3.0.co;2-6
Subject(s) - derivatization , cationic polymerization , copolymer , polymer chemistry , chemistry , chemical modification , polymer , macromolecule , materials science , organic chemistry , high performance liquid chromatography , biochemistry
In the present study the derivatization of two water‐soluble synthetic polymers, α,β‐poly( N ‐2‐hydroxyethyl)‐ DL ‐aspartamide (PHEA) and α,β‐polyasparthylhydrazide (PAHy), with glycidyltrimethylammonium chloride (GTA) is described. This reaction permits the introduction of positive charges in the macromolecular chains of PHEA and PAHy in order to make easier the electrostatic interaction with DNA. Different parameters affect the reaction of derivatization, such as GTA concentration and reaction time. PHEA reacts partially and slowly with GTA; on the contrary the reaction of PAHy with GTA is more rapid and extensive. The derivatization of PHEA and PAHy with GTA is a convenient method to introduce positive groups in their chains and it permits the preparation of interpolyelectrolyte complexes with DNA. © 2000 Society of Chemical Industry