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A novel polymeric conjugate carrying two different anticancer drugs
Author(s) -
Song SooChang,
Lee Chong Ok,
Sohn Youn Soo
Publication year - 1999
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/(sici)1097-0126(199908)48:8<627::aid-pi241>3.0.co;2-q
Subject(s) - conjugate , doxorubicin , cisplatin , carboplatin , platinum , chemistry , in vivo , combinatorial chemistry , anticancer drug , stereochemistry , pharmacology , biochemistry , chemotherapy , drug , biology , catalysis , mathematics , mathematical analysis , genetics , microbiology and biotechnology
Two different antitumour chemotherapeutic agents, doxorubicin and (dach)platinum(II) complex (dach = trans(±)‐1,2‐diaminocyclohexane) were introduced into poly(organophosphazene) using L ‐glutamic acid as a spacer. The resultant polymeric conjugates exhibited high in vivo antitumour activity which increased with increasing content of (dach)platinum(II) in the conjugates. The polymeric conjugate bearing 12.3 mol% of doxorubicin and 47.6 mol% of (dach)platinum(II) has shown the highest antitumour activity, which is higher than any one alone of cisplatin, carboplatin, or doxorubicin. © 1999 Society of Chemical Industry