Premium
Biological activity of poly(maleic acid‐ alt ‐2‐cyclohexyl‐1,3‐dioxepin‐5‐ene)
Author(s) -
Ottenbrite Raphael M.,
Liao Jun
Publication year - 1998
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/(sici)1097-0126(199807)46:3<217::aid-pi982>3.0.co;2-i
Subject(s) - maleic acid , ene reaction , chemical modification , chemistry , polymer chemistry , maleic anhydride , biological activity , polymer , copolymer , biochemistry , stereochemistry , organic chemistry , in vitro
The polyanionic polymer poly(maleic acid‐ alt ‐2‐cyclohexyl‐1,3‐dioxepin‐5‐ene), poly(MA‐CDA), was developed as an immunomodulator. It was found that the cell affinity of poly(MA‐CDA) could be significantly enhanced by hydrophobic chemical modification. This paper deals with the biological activities of poly(MA‐CDA) and hydrophobically modified poly(MA‐CDA), including immunostimulating activity, antitumour activity and antiviral activity. © 1998 SCI.