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Polysiloxanes as matrix materials for slow release of 2‐pyridine aldoxime chloride
Author(s) -
Gupta Dinesh C.,
Sumana Gajjala,
Agarwal Seema
Publication year - 1998
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/(sici)1097-0126(199802)45:2<211::aid-pi901>3.0.co;2-f
Subject(s) - pyridine , polymer , chloride , diffusion , matrix (chemical analysis) , materials science , controlled release , chemistry , fick's laws of diffusion , chemical engineering , nuclear chemistry , polymer chemistry , chromatography , organic chemistry , composite material , nanotechnology , thermodynamics , physics , engineering
The efficacy of polysiloxanes and copolysiloxanes as matrix materials for the slow release of 2‐pyridine aldoxime chloride (2‐PAM‐Cl) was investigated by in vitro studies using both slabs and microcapsules. The release rate of 2‐PAM‐Cl was determined in pH 7·4 phosphate buffer at 37°C. Transport parameters such as the Fickian coefficient, diffusion coefficient, and the polymer–2‐PAM‐Cl interaction parameter were calculated. The order of release and the time taken for 80% release were also calculated. © 1998 SCI.