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Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride–Vinyl Acetate, Maleic Anhydride–Methyl Methacrylate and Maleic Anhydride–Styrene
Author(s) -
Spridon Daniela,
Panaitescu Luminita,
Ursu Daniel,
Uglea Constantin V.,
Popa Iuliana,
Ottenbrite Raphael M.
Publication year - 1997
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/(sici)1097-0126(199706)43:2<175::aid-pi734>3.0.co;2-i
Subject(s) - maleic anhydride , copolymer , polymer chemistry , styrene , vinyl acetate , materials science , methyl methacrylate , methacrylate , biocompatibility , polymer , composite material , metallurgy
A series of maleic anhydride (MA)–vinyl acetate (VA), MA–methyl methacrylate (MM) and MA–styrene (S) copolymers were prepared and characterized. By employing various amounts of initiator, MA–VA, MA–MM and MA–S copolymers with molecular weights ranging between 18 000 and 219 000 were obtained. The ‘ in vivo ’ and ‘ in vitro ’ tests performed on K562 cellular cultures (human chronic myeloid leukaemia) and also on Westar rats (inoculated with the Walker 256 carcinosarcome) showed that, as a function of the molecular weight, the copolymers synthesized had a 50% in vitro cytotoxicity and a mean tumour regression of a maximum of 68%. © 1997 SCI.