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pH‐sensitive chitosan/gelatin hybrid polymer network microspheres for delivery of cimetidine
Author(s) -
Yao Kang De,
Xu Mei Xuan,
Yin Yu Ji,
Zhao Jin Ying,
Chen Xiu Lan
Publication year - 1996
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/(sici)1097-0126(199604)39:4<333::aid-pi502>3.0.co;2-c
Subject(s) - gelatin , chitosan , interpenetrating polymer network , cimetidine , microsphere , emulsion , polymer , drug delivery , controlled release , chemical engineering , polymer chemistry , materials science , chemistry , organic chemistry , nanotechnology , pharmacology , medicine , engineering
pH responsive chitosan/gelatin hybrid polymer network (HPN) microspheres were prepared via the inverse emulsion crosslinking method. Cimetidine release from the microspheres was studied. The drug only delivers in acidic medium, while the release rate can be controlled by the HPN composition and the degree of deacetylation.