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Oxidative stress responses of the yeast Saccharomyces cerevisiae
Author(s) -
Jamieson Derek J.
Publication year - 1998
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/(sici)1097-0061(199812)14:16<1511::aid-yea356>3.0.co;2-s
Subject(s) - saccharomyces cerevisiae , reactive oxygen species , oxidative stress , biology , yeast , superoxide , microbiology and biotechnology , lipid peroxidation , budding yeast , transcription factor , biochemistry , dna damage , oxidative phosphorylation , dna , gene , enzyme
All aerobically growing organisms suffer exposure to oxidative stress, caused by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS). These are highly reactive and capable of damaging cellular constituents such as DNA, lipids and proteins. Consequently, cells from many different organisms have evolved mechanisms to protect their components against ROS. This review concentrates on the oxidant defence systems of the budding yeast Saccharomyces cerevisiae , which appears to have a number of inducible adaptive stress responses to oxidants, such as H 2 O 2 , superoxide anion and lipid peroxidation products. The oxidative stress responses appear to be regulated, at least in part, at the level of transcription and there is considerable overlap between them and many diverse stress responses, allowing the yeast cell to integrate its response towards environmental stress. © 1998 John Wiley & Sons, Ltd.