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BTN1 , a Yeast Gene Corresponding to the Human Gene Responsible for Batten's Disease, is Not Essential for Viability, Mitochondrial Function, or Degradation of Mitochondrial ATP Synthase
Author(s) -
PEARCE DAVID A.,
SHERMAN FRED
Publication year - 1997
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/(sici)1097-0061(19970630)13:8<691::aid-yea123>3.0.co;2-d
Subject(s) - biology , atp synthase , saccharomyces cerevisiae , mitochondrion , gene , yeast , mutant , biochemistry , protein subunit , inner mitochondrial membrane , microbiology and biotechnology , genetics
The Saccharomyces cerevisiae gene BTN1 , encodes a 408 amino acid putative integral membrane protein, which is 39% identical and 59% similar to the human Cln3p, whose mutant forms are responsible for Batten's disease and for a diminished degradation of mitochondrial ATPase synthase subunit c . Disruption experiments established that Btn1p is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase in yeast. © 1997 John Wiley & Sons, Ltd.