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Sequence Analysis of Candida albicans Phosphoribosyl‐aminoimidazole Carboxylase ( ADE2 ) Gene
Author(s) -
Tsang WaiKei Paul,
Cao BoYang,
Wang Jun
Publication year - 1997
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/(sici)1097-0061(19970615)13:7<673::aid-yea122>3.0.co;2-g
Subject(s) - biology , genbank , schizosaccharomyces pombe , nucleic acid sequence , gene , peptide sequence , open reading frame , candida albicans , homology (biology) , sequence analysis , genetics , biochemistry , amino acid , microbiology and biotechnology , saccharomyces cerevisiae
The nucleotide sequence of the Candida albicans ADE2 gene, which encodes phosphoribosylaminoimidazole carboxylase, has been determined. The sequence possesses an uninterrupted open reading frame of 1704 nucleotides corresponding to 568 amino acid residues. The deduced amino acid sequence shares a high degree of homology with ADE2 homologues in other fungal species including Saccharomyces cerevisiae , Pichia methanolica , Schwanniomyces occidentalis and Schizosaccharomyces pombe . Three regions of amino acid sequence were highly conserved among all reported ADE2 genes. The hexanucleotide TGACTC characteristic of genes involved in purine and amino acid biosyntheses is located in front of putative TATA boxes in the promoter region. The GenBank Accession Number of this gene is U75582. © John Wiley & Sons, Ltd.