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The DNA sequence of cosmid 14‐5 from chromosome XIV reveals 21 open reading frames including a novel gene encoding a globin‐like domain
Author(s) -
Pandolfo Davide,
de Antoni Anna,
Lanfranchi Gerolamo,
Valle Giorgio
Publication year - 1996
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/(sici)1097-0061(199609)12:10b<1071::aid-yea4>3.0.co;2-s
Subject(s) - orfs , cosmid , biology , genetics , open reading frame , gene , peptide sequence
In this paper is described the DNA sequence of cosmid 14‐5 from chromosome XIV of Saccharomyces cerevisiae . The sequence is 38 855 bases long and contains 21 open reading frames (ORFs) plus three internal ORFs. Six ORFs correspond to known yeast genes ( SLA2, ZWF1, BLH1, KEX2, SIN4 and URE2 ); two other ORFs had already been sequenced because they are adjacent to known genes; the remaining 12 ORFs are novel genes. Of these, one ORF ( N1142 ) is particularly interesting since it shows a significant similarity to mammalian globin. Another ORF ( N1254 ) displays two zinc finger motifs as well as a DNAJ motif. The cosmid sequence has been submitted to the EMBL data library under Accession Number Z69381.