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ERG1 , encoding squalene epoxidase, is located on the right arm of chromosome VII of Saccharomyces cerevisiae
Author(s) -
Landl Karina M.,
Klösch Burkhard,
Turnowsky Friederike
Publication year - 1996
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/(sici)1097-0061(199605)12:6<609::aid-yea949>3.0.co;2-b
Subject(s) - ergosterol , squalene monooxygenase , ura3 , saccharomyces cerevisiae , biology , gene , chromosome , squalene , genetics , yeast , biochemistry , biosynthesis
The ERG1 gene of Saccharomyces cerevisiae encodes squalene epoxidase, a key enzyme in the ergosterol pathway. ERG1 is an essential gene. Disruption of the gene with URA3 results in a lethal phenotype when cells are grown under aerobic conditions, even in the presence of ergosterol. However, cells are viable in the presence of ergosterol under anaerobic growth conditions during which ergosterol is taken up by cells. Physical and genetic mapping data reveal that ERG1 is located on the right arm of chromosome VII proximal to QCR9 at a distance of 14·6 cM from ADE3 .