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Relationship of p21 WAF1 expression with disease‐free survival and biochemical recurrence in prostate adenocarcinomas (PCa)
Author(s) -
Sarkar Fazlul H.,
Li Yiwei,
Sakr Wael A.,
Grig David J.,
Madan Shahi S.,
Wood David P.,
Adsay Volkan
Publication year - 1999
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(19990901)40:4<256::aid-pros7>3.0.co;2-i
Subject(s) - biochemical recurrence , prostate , medicine , prostate disease , oncology , disease , prostate cancer , adenocarcinoma , prostatic disease , pathology , prostatectomy , cancer
BACKGROUND The p21 WAF1 gene is considered to be one of the major regulators of the cell cycle. Its level of expression has been shown to correlate with pathologic stage and Gleason score in prostatic cancer. However, its relationship to clinical outcome is not yet well‐characterized. METHODS Immunohistochemical staining for p21 WAF1 protein expression was performed in 62 consecutive radical prostatectomy specimens from our institution. The results were correlated with the disease‐free survival and biochemical recurrence of the patients. RESULTS Thirty‐four of the 62 patients were Caucasian and 28 were African American. There was a significant correlation between p21 WAF1 expression and biochemical recurrence after radical prostatectomy ( P < 0.0095). However, while p21 WAF1 staining in prostate cancer was a prognostic indicator of disease‐free survival in Caucasians ( P < 0.0001), it appeared not to be a factor in African‐American men ( P = 0.908). CONCLUSIONS This study suggests that p21 WAF1 may have a role in the pathogenesis and progression of prostate carcinoma, and may serve as a predictor of biochemical recurrence of this tumor. The differences in the values of p21 WAF1 as a prognostic marker of disease‐free survival in Caucasians vs. African Americans suggest that progression of prostate cancer may have different mechanisms in different ethnic groups. Prostate 40:256–260, 1999. © 1999 Wiley‐Liss, Inc.