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Testosterone‐induced prostatic growth in the rat causes bladder overactivity unrelated to detrusor hypertrophy
Author(s) -
Pandita Raj Kumar,
Persson Katarina,
Hedlund Petter,
Andersson KarlErik
Publication year - 1998
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(19980501)35:2<102::aid-pros3>3.0.co;2-l
Subject(s) - urination , medicine , prostate , testosterone propionate , testosterone (patch) , muscle hypertrophy , urology , lower urinary tract symptoms , endocrinology , urinary system , bladder outlet obstruction , androgen , hormone , cancer
BACKGROUND Testosterone treatment of rats produces prostatic hypertrophy and detrusor overactivity. Whether or not the detrusor overactivity can be related to an increase in the responsiveness of lower urinary tract smooth muscles is not known. METHODS Male Sprague‐Dawley rats were given daily injections of testosterone propionate for 2 weeks. Effects on cystometric parameters and on the responsiveness of isolated detrusor, urethral, and prostate smooth muscle preparations to drugs and electrical field stimulation were investigated. RESULTS Testosterone treatment increased prostatic weight twofold (controls, 768 mg; testosterone‐treated, 1,478 mg), but not bladder weight (103 mg vs. 116 mg). Micturition pressure (77%), bladder capacity (75%), residual volume (56%), and micturition volume (83%) increased significantly in treated animals, and bladder overactivity developed. No effect of intraarterial doxazosin on these changes was observed. The differences in urodynamic parameters between control and testosterone‐treated rats could not be correlated with changes in bladder, urethral, or prostate excitatory innervation, as revealed by responses to electrical field stimulation, or by smooth muscle responses to different contractant drugs. CONCLUSIONS Some of the urodynamic effects seen after testosterone treatment seem to be caused by the mechanical obstruction of the enlarged prostate. Since there were no changes in smooth muscle responsiveness, it is suggested that the bladder overactivity observed can partly be related to testosterone‐induced changes of the micturition reflex at the lower urinary tract, spinal, and/or supraspinal levels. Prostate 35:102–108, 1998. © 1998 Wiley‐Liss, Inc.