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Transurethral microwave thermotherapy in symptomatic benign prostatic hyperplasia: A possible association between androgen status and treatment result?
Author(s) -
Hallin Anders,
Stege Reinhard,
Berlin Tomas,
Carlström Kjell
Publication year - 1997
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(19970915)33:1<13::aid-pros3>3.0.co;2-a
Subject(s) - medicine , endocrine system , prostate , urology , androgen , testosterone (patch) , hyperplasia , antiandrogen , gynecology , hormone , cancer
BACKGROUND Nothing is yet known of possible endocrine effects of transurethral microwave thermotherapy (TUMT) or of possible influence of endocrine status on the result of thermotherapy. METHODS Serum levels of testosterone (T), SHBG, estradiol, LH, and FSH were measured in 48 men with BPH before and 2–3 months after TUMT (Prostatron®, Prostasoft 2.0; Technomed International, Lyon, France). Assessment of results was based on the patients' own estimations. RESULTS The treatment did not alter hormone levels. Patients who reported response after 12 months (n = 21) had significantly lower outset levels of calculated free testosterone (fT) than in the nonresponders (n = 27). In the patients aged <70 years (n = 13), both the fT and T values were lower than in the nonresponders (n = 15). There was no age difference between responders and nonresponders. CONCLUSIONS TUMT did not influence hormone levels. These observations suggest that androgen status may influence the final result of treatment. Prostate 33:13–17, 1997. © 1997 Wiley‐Liss, Inc.