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Effect of active immunization against luteinizing hormone‐releasing hormone on the androgen‐sensitive Dunning R3327‐PAP and androgen‐independent Dunning R3327‐AT2.1 prostate cancer sublines
Author(s) -
Fuerst Johannes,
Fiebiger Eduard,
Jungwirth Andreas,
Mack Doris,
Talwar Pran G.,
Frick Julian,
Rovan Erwin
Publication year - 1997
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(19970701)32:2<77::aid-pros1>3.0.co;2-c
Subject(s) - androgen , medicine , prostate cancer , endocrinology , testosterone (patch) , prostate , biology , cancer research , cancer , hormone
BACKGROUND The objective of this study was to determine the effect of active immunization against LHRH on the growth characteristics and histology of subcutaneously implanted tumors of the androgen‐sensitive Dunning R3327‐PAP and androgen‐independent R3327‐AT2.1 rat prostate adenocarcinoma sublines. RESULTS We herein demonstrate that 1) active immunization with an LHRH‐diphtheria toxoid‐conjugate (LHRH‐DT) leads to the downregulation of gonadotrophins and testosterone and consequently the atrophy of testosterone‐dependent organs such as the testes, prostate, and androgen‐sensitive Dunning R3327‐PAP tumors, 2) growth inhibition of Dunning R3327‐PAP tumors is caused by suppression of cell division rather than by an increase in cell death and is associated with an increase of the tumor stroma content, and 3) volume increase of the androgen‐independent Dunning R3327‐AT2.1 tumor is slightly but significantly reduced, indicating a local stimulatory LHRH loop with within this tumor cell line. Prostate 32:77–84, 1997. © 1997 Wiley‐Liss, Inc.