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Proton MRS of human prostatic fluid: Correlations between citrate, spermine, and myo ‐inositol levels and changes with disease
Author(s) -
Lynch Michael J.,
Nicholson Jeremy K.
Publication year - 1997
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(19970301)30:4<248::aid-pros4>3.0.co;2-h
Subject(s) - spermine , endocrinology , prostate , medicine , chemistry , prostatic diseases , cancer , biochemistry , enzyme
BACKGROUND This is a study of the unusual small molecular components of human prostatic fluid using a non‐destructive technique. METHODS Single pulse high resolution proton MRS of 38 human prostatic fluid samples (12 control, 10 with benign prostatic enlargement, 4 with prostatic cancer, 11 with vasal aplasia, and one with prostatodynia). Regression models for the metabolites measured were made and compared, and correlations were analyzed. RESULTS A very strong correlation between the secretion of citrate and spermine (r=0.94), two of the major components of prostatic fluid, was found. The molar ratio was 5:1 citrate: spermine. There was no difference seen between samples obtained by expression or ejaculation. The regression models suggest there is a significant difference ( P <0.02) in the citrate to spermine ratio in prostatic fluid from men with prostate cancer, with a relatively higher level of spermine. CONCLUSIONS The authors speculate that citrate and spermine secretion is linked and may be forming a novel complex. Prostate 30:248–255, 1997. © 1997 Wiley‐Liss, Inc.