Premium
Lectin‐like receptor for α 1 ‐acid glycoprotein in the epithelium of the rat prostate gland and seminal vesicles
Author(s) -
Andersen Ulla Overgaard,
BøgHansen Thorkild C.,
Kirkeby Svend
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(199612)29:6<356::aid-pros3>3.0.co;2-6
Subject(s) - prostate , epithelium , glycoprotein , lectin , seminal vesicle , prostate gland , receptor , vesicle , biology , microbiology and biotechnology , endocrinology , medicine , pathology , chemistry , biochemistry , cancer , membrane
BACKGROUND A receptor for α 1 ‐acid glycoprotein glycoforms AGP‐B and AGP‐C in the epithelium of the rat prostate gland and seminal vesicles is described. METHODS The interaction between AGP‐glycoforms and their receptor is a lectin‐like interaction confirmed by inhibition of the binding by mannose and N‐Acetyl‐D‐glucosamine. RESULTS In vitro the receptor was also inhibited by the steroid hormones cortisone, aldosterone, progesterone, and estradiol, but not by testosterone. A significant regional variation in the expression of AGP‐lectin receptor and in the localization of AGP was seen in rat prostate and seminal vesicles. The localization of the AGP lectin receptor is compared to the localization of glycoprotein AGP, and small differences are found. CONCLUSIONS It is proposed the AGP receptors in the prostate and seminal vesicles belong to a group of lectins in the control of differentiation and organ formation. © 1996 Wiley‐Liss, Inc.