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Standardized assessment to enhance the diagnostic value of prostate volume; Part II: Correlation with prostate‐specific antigen levels
Author(s) -
Aarnink René G.,
de la Rosette Jean J.M.C. H.,
Huynen Anton L.,
Giesen Robert J. B.,
Debruyne Frans M. J.,
Wijkstra Hessel
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(199611)29:5<327::aid-pros8>3.0.co;2-6
Subject(s) - prostate , prostate specific antigen , medicine , urology , prostate cancer , correlation , mathematics , cancer , geometry
BACKGROUND Standardized estimations of prostate volumes are used for interpretation of prostate specific antigen (PSA) levels. METHODS In 243 patients with clinically benign diagnosis, automated and reference prostate volumes and transition zone volumes are correlated to PSA levels. Besides, growth curves of PSA level when aging are determined. RESULTS The strongest correlation was found with multiple regression analysis between PSA and transition zone volume and rest volume (R = 0.854). Mean PSA density was 0.092 ng/mL 2 , its labelling quality for benign disease was 91% (threshold = 0.15 ng/mL 2 ). An average growth factor for PSA levels of 2.9% per year was obtained. CONCLUSIONS The contribution per unit tissue to PSA level was for the transition zone 1.9 times higher than for the rest volume. Average growth of PSA per year is in consonance with the increase in normal levels of age specific PSA ranges, although only weak correlations were found between PSA and age and PSA density and age. © 1996 Wiley‐Liss, Inc.