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Effects of finasteride on health‐related quality of life in men with symptomatic benign prostatic hyperplasia
Author(s) -
Girman Cynthia J.,
Kolman Christopher,
Liss Charles L.,
Bolognese James A.,
Binkowitz Bruce S.,
Stoner Elizabeth
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(199608)29:2<83::aid-pros3>3.0.co;2-i
Subject(s) - finasteride , medicine , worry , quality of life (healthcare) , sexual function , placebo , hyperplasia , disease , gynecology , urology , prostate , anxiety , pathology , psychiatry , alternative medicine , nursing , cancer
The effects of urinary symptoms on health‐related quality of life (HRQL) are important in therapeutic decision making. Few have evaluated the treatment effects on HRQL in men with benign prostatic hyperplasia (BPH), even though increased urinary symptoms are associated with greater worry, bother, and interference with living activities. We report on patient assessments of such disease‐specific measures as well as general HRQL measures from two placebo‐controlled clinical trials of finasteride in the treatment of symptomatic BPH. Patients treated with finasteride appeared to have greater improvement than placebo‐treated patients in disease‐specific measures and in patient global assessment. The treated group appeared to have a greater mean increase in sexual domain scores. As expected, general measures (health rating, life satisfaction, ladder of life) changed little. Thus, treatment with finasteride appears to reduce bother, worry, and activity interference due to symptoms but in a small percentage of men may lead to slightly reduced sexual function. © 1996 Wiley‐Liss, Inc.