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Relative and total volume of histological components in benign prostatic hyperplasia: Relationships between histological components and clinical findings
Author(s) -
Ishigooka Manabu,
Hayami Shinsuke,
Hashimoto Tohru,
Suzuki Yasuhiro,
Katoh Tomoyuki,
Nakada Teruhiro
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(199608)29:2<77::aid-pros2>3.0.co;2-e
Subject(s) - hyperplasia , prostate , medicine , pathology , volume (thermodynamics) , histology , prostatic diseases , urology , anatomy , cancer , physics , quantum mechanics
To investigate the correlation between histological differences and clinical findings in patients with benign prostatic hyperplasia (BPH), quantitative morphometrical analysis on prostate was performed on 26 specimens obtained by TURP. The relative and total volume of each histological component were obtained. In this series, the proportion of fibrous tissue element showed a weak positive correlation with prostatic volume (r = 0.499, P = 0.0087). The relative volume of the smooth muscle component showed an inverse correlation with prostatic volume (r = −0.488, P = 0.0105). Patient age and symptom score showed no relationship with the relative volume of histological components. The total volume of all histological components increased with prostatic volume. However, an increase in the fibrous tissue element appeared to be predominant in prostatic enlargement (r = 0.970, P < 0.0001). Although the total volume of all histological components increased with prostatic size, fibrous tissue appeared to play a major role in prostatic enlargement in BPH. © 1996 Wiley‐Liss, Inc.