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In situ hybridization studies of α 2 ‐macroglobulin receptor and receptor‐associated protein in human prostate carcinoma
Author(s) -
McGarvey T.,
Hussain M. M.,
Stearns M. E.
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(199605)28:5<311::aid-pros7>3.0.co;2-e
Subject(s) - prostate cancer , prostate , in situ hybridization , immunocytochemistry , pathology , receptor , alpha (finance) , medicine , carcinoma , pca3 , prostate carcinoma , cancer , messenger rna , biology , cancer research , gene , biochemistry , construct validity , nursing , patient satisfaction
We have utilized in situ hybridization and immunocytochemistry techniques to examine the expression of both α 2 ‐macroglobulin (α 2 ‐MR) and the 39 kDa receptor‐associated protein (RAP) in 8 benign (BPH) and 34 malignant human prostate tissues, including 4 metastases. The levels of α 2 ‐MR mRNA expression (but not RAP) increased significantly in high Gleason score carcinomas (>8) and in metastatic lesions, suggesting that α 2 ‐MR expression is associated with advanced cancer. Semi‐quantitative analysis with computer‐assisted system analysis (CASA) confirmed this interpretation. This is the first report of α 2 ‐MR expression being associated with advanced prostate cancer. © 1996 Wiley‐Liss, Inc.