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Loss of heterozygosity on chromosomes 10 and 17 in clinically localized prostate carcinoma
Author(s) -
Ittmann Michael M.
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(199605)28:5<275::aid-pros1>3.0.co;2-b
Subject(s) - loss of heterozygosity , monosomy , biology , tumor suppressor gene , chromosome , prostate , prostate cancer , cancer research , microsatellite , carcinoma , suppressor , chromosome 17 (human) , pathology , karyotype , gene , genetics , cancer , carcinogenesis , medicine , allele
Loss of heterozygosity (LOH) at chromosomal loci has been associated with the presence of tumor suppressor genes at the deleted loci. Twenty‐six clinically localized, Stage B prostate carcinomas were analyzed for LOH on chromosomes 10 and 17 using microsatellite markers. Two of 26 carcinomas showed LOH on 17p while one showed LOH on 17q. Chromosome 10 showed a complex pattern of LOH with monosomy (1 case), LOH on 10p (1 case), proximal 10q (1 case) and distal 10q (2 cases). Overall 29% of informative cases showed LOH on chromosome 10. These results are consistent with the presence of a tumor suppressor for prostate cancer on 17p and multiple tumor suppressor genes on chromosome 10. © 1996 Wiley‐Liss, Inc.