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Benign prostatic hyperplasia: A review of its histogenesis and natural history
Author(s) -
Oesterling Joseph E.
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(1996)6+<67::aid-pros13>3.0.co;2-p
Subject(s) - hyperplasia , histogenesis , prostate , medicine , natural history , etiology , stromal cell , urology , pathology , cancer , immunohistochemistry
Although the exact etiology of benign prostatic hyperplasia (BPH) is not well‐defined, it is thought to occur as a result of epithelial‐stromal interactions in the appropriate hormonal milieu. Benign prostatic hyperplasia originates in the periurethral and transition zones of the prostate in a microscopic (histologically identifiable) state as early as the third decade of life. With advancing age and the presence of androgens, approximately 50% of microscopic BPH will develop into macroscopic (palpably enlarged prostate) BPH. However, clinically significant BPH, necessitating treatment, will develop in only 50% of men with an enlarged prostate gland. In the United States, the estimated risk of a 50‐year‐old man undergoing therapeutic intervention in his lifetime is approximately 40%. If left untreated, a significant number of symptomatic patients will remain stable or improve without adverse sequelae. © 1996 Wiley‐Liss, Inc.