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DNA methylation, molecular genetic, and linkage studies in prostate cancer
Author(s) -
Jarrard David F.,
Bova G. Steven,
Isaacs William B.
Publication year - 1996
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co;2-i
Subject(s) - epigenetics , prostate cancer , dna methylation , biology , chromoplexy , gene , genetics , prostate , cancer , point mutation , cancer research , methylation , tumor suppressor gene , suppressor , locus (genetics) , mutation , carcinogenesis , pca3 , gene expression
Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals. © 1996 Wiley‐Liss, Inc.