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Regulation of intermediate filament organization during cytokinesis: Possible roles of Rho‐associated kinase
Author(s) -
Goto Hidemasa,
Kosako Hidetaka,
Inagaki Masaki
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(20000415)49:2<173::aid-jemt10>3.0.co;2-a
Subject(s) - cytokinesis , microbiology and biotechnology , mitosis , cleavage furrow , cleavage (geology) , phosphorylation , cytoskeleton , kinase , biology , protein filament , gtpase , aurora b kinase , chemistry , cell division , cell , biochemistry , paleontology , fracture (geology)
Intermediate filaments (IFs), which form the structural framework of cytoskeleton, have been found to be dramatically reorganized during mitosis. Some protein kinases activated in mitosis are thought to control spatial and temporal IF reorganization through phosphorylation of IF proteins. Rho‐associated kinase (Rho‐kinase), one of the putative targets of the small GTPase Rho, does phosphorylate IF proteins, specifically at the cleavage furrow during cytokinesis. This cleavage furrow‐specific phosphorylation plays an important role in the local IF breakdown and efficient separation of IF networks. Recent studies on Rho signaling pathways have introduced new models about the molecular mechanism of rearrangements of cytoskeletons including IFs during cytokinesis. Microsc. Res. Tech. 49:173–182, 2000. © 2000 Wiley‐Liss, Inc.