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Involvement of PCH family proteins in cytokinesis and actin distribution
Author(s) -
Lippincott John,
Li Rong
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(20000415)49:2<168::aid-jemt9>3.0.co;2-t
Subject(s) - cytokinesis , biology , septin , microbiology and biotechnology , yeast , budding yeast , schizosaccharomyces pombe , homology (biology) , protein family , actin , function (biology) , genetics , saccharomyces cerevisiae , cell division , cell , gene
Pombe Cdc15 homology (PCH) proteins constitute an extensive protein family whose members have been found in diverse eukaryotic organisms. These proteins are characterized by the presence of several conserved sequence and structural motifs. Recent studies in yeast and mammalian cultured cells have implicated these proteins in actin‐based processes, in particular, cytokinesis. Here we review the recent findings on the in vivo localization, function, and binding partners of PCH family members. We also provide new microscopy data regarding the in vivo dynamics of a budding yeast PCH protein involved in cytokinesis. Microsc. Res. Tech. 49:168–172, 2000. © 2000 Wiley‐Liss, Inc.