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MAP1B expression and microtubule stability in growing and regenerating axons
Author(s) -
GordonWeeks Phillip R.,
Fischer Itzhak
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(20000115)48:2<63::aid-jemt2>3.0.co;2-1
Subject(s) - microtubule , phosphoprotein , microbiology and biotechnology , neurite , microtubule associated protein , biology , kinase , phosphorylation , growth cone , neuroscience , axon , genetics , in vitro
MAP1B is a microtubule‐associated phosphoprotein that is particularly highly expressed in developing neurons. There is experimental evidence that it plays an important role in neuronal differentiation, especially the extension of axons and dendrites, but exactly what role is unclear. Recent experiments have shed light on the gene structure of MAP1B and identified some of the kinases that phosphorylate the protein. Implicit in these findings is the idea that MAP1B regulates the organisation of microtubules in neurites and is itself regulated in a complex way and at a number of levels. Microsc. Res. Tech. 48:63–74, 2000. © 2000 Wiley‐Liss, Inc.