Premium
Structure, assembly, and dynamics of actin filaments in situ and in vitro
Author(s) -
Schoenenberger CoraAnn,
Steinmetz Michel O,
Stoffler Daniel,
Mandinova Anna,
Aebi Ueli
Publication year - 1999
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(19991001)47:1<38::aid-jemt4>3.0.co;2-5
Subject(s) - gene isoform , actin , biology , microbiology and biotechnology , in situ , computational biology , evolutionary biology , in vitro , genetics , chemistry , gene , organic chemistry
Actin, though highly conserved, exhibits a myriad of diverse functions, most of which ultimately depend on its intrinsic ability to rapidly assemble and disassemble filamentous structures. Many organisms synthesize multiple actin isoforms even within the same cell. Tissue‐specific expression patterns and tight developmental regulation as well as a high conservation across species emphasize the functional importance of isoforms. The detailed knowledge of the structure, assembly, and dynamic behavior of actin provides important pieces in solving the puzzle of how the different isoforms can be so versatile despite their extremely high sequence identity. Microsc. Res. Tech. 47:38–50, 1999. © 1999 Wiley‐Liss, Inc.