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Trks: Signal transduction and intracellular pathways
Author(s) -
Klesse Laura J.,
Parada Luis F.
Publication year - 1999
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(19990515/01)45:4/5<210::aid-jemt4>3.0.co;2-f
Subject(s) - trk receptor , neurotrophin , tropomyosin receptor kinase a , signal transduction , biology , microbiology and biotechnology , neuroscience , intracellular , receptor tyrosine kinase , nerve growth factor , low affinity nerve growth factor receptor , kinase , tropomyosin receptor kinase c , receptor , platelet derived growth factor receptor , growth factor , genetics
The neurotrophin family of growth factors supports survival and differentiation of neurons in the developing vertebrate nervous system by binding activating receptor tyrosine kinases, the Trks. Activation of Trk receptors leads to stimulation of a number of intracellular signaling cascades including, among others, the ras/extracellular regulated kinase (erk) and the phosphatidylinositol‐3 kinase (PI 3 kinase) cascades. Over the past several years, work in several neurotrophin responsive systems has begun to identify the role each of these signaling cascades plays in the cellular response to neurotrophins. It now appears that neurotrophins, in particular nerve growth factor (NGF), mediate their multiple effects through a number of distinct intracellular signaling cascades. In this review, we will overview the evidence implicating specific signaling cascades in aspects of the cellular response to the neurotrophins, specifically in response to activation of TrkA by NGF. Microsc. Res. Tech. 45:210–216, 1999. © 1999 Wiley‐Liss, Inc.