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Contributions of the epidermal growth factor receptor to keratinocyte motility
Author(s) -
Hudson Laurie G.,
McCawley Lisa J.
Publication year - 1998
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(19981201)43:5<444::aid-jemt10>3.0.co;2-c
Subject(s) - motility , epidermal growth factor receptor , keratinocyte , keratinocyte growth factor , microbiology and biotechnology , epidermal growth factor , biology , receptor , chemistry , growth factor , genetics , in vitro
The epidermal growth factor (EGF) receptor plays a central role in numerous aspects of keratinocyte biology. In normal epidermis, the EGF receptor is important for autocrine growth of this renewing tissue, suppression of terminal differentiation, promotion of cell survival, and regulation of cell migration during epidermal morphogenesis and wound healing. In wounded skin, the EGF receptor is transiently up‐regulated and is an important contributor to the proliferative and migratory aspects of wound reepithelialization. In keratinocytic carcinomas, aberrant expression or activation of the EGF receptor is common and has been proposed to play a role in tumor progression. Many cellular processes such as altered cell adhesion, expression of matrix degrading proteinases, and cell migration are common to keratinocytes during wound healing and in metastatic tumors. The EGF receptor is able to regulate each of these cellular functions and we propose that transient and dynamic elevation of EGF receptor during wound healing, or constitutive overexpression in tumors, provides an important contribution to the migratory and invasive potential of keratinocytes. Microsc. Res. Tech. 43:444–455, 1998. © 1998 Wiley‐Liss, Inc.