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Regulation of integrin‐mediated adhesion during cell migration
Author(s) -
Cox Elisabeth A.,
Huttenlocher Anna
Publication year - 1998
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(19981201)43:5<412::aid-jemt7>3.0.co;2-f
Subject(s) - integrin , microbiology and biotechnology , extracellular matrix , fibronectin , cell migration , cell adhesion , adhesion , focal adhesion , podosome , adhesive , calpain , cell , tyrosine phosphorylation , extracellular , chemistry , phosphorylation , biology , cytoskeleton , biochemistry , enzyme , organic chemistry , layer (electronics)
Migrating cells form dynamic and highly regulated adhesive interactions with their environment. In particular, integrin‐mediated adhesions to the extracellular matrix (ECM) play a central role in cell migration. This review focuses on recent advances in understanding the adhesive mechanisms that regulate cell detachment at the rear of migrating fibroblasts and neutrophils. The contribution of several key adhesive regulators is discussed, including myosin mediated cell contractility, tyrosine phosphorylation, rho, calcium fluxes, and calpain. A challenge for future investigation will be to determine how adhesive events are spatially and temporally coordinated to promote productive directional cell movements. Microsc. Res. Tech. 43:412–419, 1998. © 1998 Wiley‐Liss, Inc.