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Adhesion‐guided in vitro morphogenesis in pure and mixed cell cultures
Author(s) -
Powers Mark J.,
Griffith Linda G.
Publication year - 1998
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(19981201)43:5<379::aid-jemt4>3.0.co;2-0
Subject(s) - morphogenesis , cytoarchitecture , microbiology and biotechnology , biology , cell adhesion , in vitro , adhesion , cell , tissue engineering , chemistry , anatomy , genetics , organic chemistry , gene
The ability to understand and control the morphogenesis of mammalian cells is a fundamental objective of cell and developmental biology and tissue engineering research. Numerous processes, both biochemical and biophysical in nature, have been studied in an attempt to elucidate the mechanisms underlying this behavior. We focus here on the contributions of biophysical phenomena to the morphogenetic behavior of pure and mixed cell populations on solid surfaces in vitro. These principles are illustrated using characteristic liver tissue cells as a model system. The studies discussed demonstrate that cell‐substratum and cell‐cell adhesive forces are critical determinants of the ultimate morphology, cytoarchitecture, and organization achieved by these cells in vitro. Microsc. Res. Tech. 43:379–384, 1998. © 1998 Wiley‐Liss, Inc.