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Morphology of lipid alterations in the epidermis: A review
Author(s) -
Me Gopinathan,
Ghadially Ruby
Publication year - 1997
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/(sici)1097-0029(19970501)37:3<180::aid-jemt3>3.0.co;2-s
Subject(s) - stratum corneum , ultrastructure , epidermis (zoology) , lipid metabolism , corneocyte , barrier function , pathology , biology , chemistry , microbiology and biotechnology , biochemistry , medicine , anatomy
An overview of the morphological correlates of mammalian epidermal lipids and the cutaneous permeability barrier is provided. The following features are discussed: 1) ultrastructural characterization of the progressive lipid alterations accompanying normal stratum corneum (SC) formation; 2) effects of drugs/inhibitors that interfere with specific aspects of epidermal lipid metabolism; 3) lipid alterations in certain human skin disorders; 4) effects of selected topical emollients on SC lipid organization; and 5) potential pitfalls in interpretation of ultrastructural data in terms of cutaneous function and dysfunction. Microsc. Res. Tech., 37:180–192, 1997. © 1997 Wiley‐Liss, Inc.