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Toxicological evaluation of acetylated faba bean globulin
Author(s) -
Schmandke Horst,
Plass Roland,
Lewerenz HansJochen,
Bleyl Dietmar W R
Publication year - 2000
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/(sici)1097-0010(20000101)80:1<109::aid-jsfa497>3.0.co;2-f
Subject(s) - globulin , chemistry , toxicology , biology , agronomy , immunology
Abstract Acetylated faba bean globulin (acVFG, acetylation degree 97%) was evaluated toxicologically in a subchronic feeding study and a female fertility test. Groups of male and female rats received acVFG in their diet at levels of 20, 40 and 80 g kg −1 for 3 months. Additional groups were fed a commercial diet or given food containing 38 or 75 g kg −1 casein. The subchronic toxicity study revealed growth retardation in both sexes at the 80 g kg −1 acVFG level. The food consumption was reduced in males at 40 and 80 g kg −1 acVFG and in females at 80 g kg −1 acVFG. Histopathological alterations in the ovaries were observed at dietary levels of 40 and 80 g kg −1 acVFG. Histopathological changes and decreases in the absolute and relative weight of the uterus were found in all groups fed acVFG. Therefore a no‐observed‐effect level (NOEL) was not derivable. Feeding females 80 g kg −1 acVFG resulted in diminished pre‐implantation losses but increased post‐implantation losses in the fertility study. © 2000 Society of Chemical Industry