Premium
Antioxidant Action of Tetrandrine: An Alkaloid from the Roots of Radix stephania tetrandra , S Moore
Author(s) -
Cao Zhaofeng,
Zhu Xinqiu
Publication year - 1997
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/(sici)1097-0010(199701)73:1<106::aid-jsfa714>3.0.co;2-a
Subject(s) - tetrandrine , chemistry , antioxidant , ascorbic acid , alkaloid , lipid peroxidation , scavenger , bleomycin , biochemistry , stereochemistry , pharmacology , food science , biology , genetics , chemotherapy
The antioxidant action of the alkaloid tetrandrine(TD), was investigated using systems generating biologically relevant reactive oxygen species. TD appeared to scavenge OH • produced in a mixture of EDTA‐Fe 3+ /ascorbate and H 2 O 2 and suppressed the peroxidation of phospholipid liposomes in the presence of iron(III) and ascorbate. TD was a good scavenger toward trichloromethyl peroxyl with a rate constant of 6·5±0·3×10 7 M ‐1 s ‐1 generated by pulse radiolysis. TD did not promote DNA damage in the bleomycin‐Fe 3+ system and a concentration up to 500 μ M produced a weak inhibition of DNA damage by bleomycin‐Fe 3+ in the presence of ascorbic acid. The present data suggest that TD possess antioxidant properties. © 1997 SCI.