Premium
Multiple ‘serrated adenocarcinomas’ of the colon with a cell lineage common to metaplastic polyp and serrated adenoma. Case report of a new subtype of colonic adenocarcinoma with gastric differentiation
Author(s) -
Yao Takashi,
Nishiyama Kenichi,
Oya Masafumi,
Kouzuki Toshio,
Kajiwara Masaaki,
Tsuneyoshi Masazumi
Publication year - 2000
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(200003)190:4<444::aid-path520>3.0.co;2-o
Subject(s) - hyperplastic polyp , adenocarcinoma , immunohistochemistry , pathology , carcinoma , lineage (genetic) , adenoma , mucin , medicine , biology , colorectal cancer , cancer , biochemistry , colonoscopy , gene
A 70‐year‐old woman underwent right hemicolectomy and six carcinomas were recognized in the resected colon. These carcinomas were considered to be of a cell lineage common to serrated adenoma (SA) and hyperplastic (metaplastic) polyp (H/MP), because of the occurrence of multiple SAs and H/MPs around the carcinomas, as well as the co‐existence of SA and H/MP areas within the carcinomas. These carcinomas had the following common histological and immunohistochemical features: a serrated structure resembling SA; a lace‐like structure; infiltrative growth within the muscularis propria, with dedifferentiation at the invasive front; and immunohistochemical expression of pS2 and human gastric mucin. Based on these features, a new subtype of carcinoma is proposed, with a cell lineage common to SA and H/MP. It would also seem that p53 is involved in the serrated adenoma–carcinoma sequence. Copyright © 2000 John Wiley & Sons, Ltd.