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Chondroblastoma is an osteoid‐forming, but not cartilage‐forming neoplasm
Author(s) -
Aigner Thomas,
Loos Stefan,
Inwards Carrie,
Perris Roberto,
Perissinotto Daniela,
Unni K. Krishnan,
Kirchner Thomas
Publication year - 1999
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199912)189:4<463::aid-path476>3.0.co;2-n
Subject(s) - chondroblastoma , extracellular matrix , cartilage , osteoid , pathology , type ii collagen , matrix (chemical analysis) , anatomy , aggrecan , biology , chemistry , microbiology and biotechnology , medicine , osteoarthritis , articular cartilage , alternative medicine , chromatography
Chondroblastoma is defined as a ‘benign tumour, characterized by highly cellular and relatively undifferentiated tissue composed of rounded or polygonal chondroblast‐like cells’ and the ‘presence of cartilaginous intercellular matrix’ (WHO). An extensive analysis of the extracellular matrix composition and gene expression pattern of a large series of chondroblastoma cases shows, however, that type II collagen, which is the main component of any cartilage matrix, is not expressed by the neoplastic cells of this tumour entity and is not deposited into the extracellular tumour matrix. Instead, osteoid and fibrous matrix is formed, with its typical biochemical composition. The multifocal expression of aggrecan proteoglycan in most chondroblastomas explains the bluish, pseudo‐chondroid appearance of some of the matrix‐rich areas of chondroblastomas. This study did not show chondroid matrix formation or chondroblastic cell differentiation in chondroblastomas, suggesting that chondroblastoma should be classified as a specific bone‐forming, rather than cartilage‐forming neoplasm. Copyright © 1999 John Wiley & Sons, Ltd.