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Do HPV‐negative cervical carcinomas exist?—revisited
Author(s) -
Herrington C. Simon
Publication year - 1999
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/(sici)1096-9896(199909)189:1<1::aid-path432>3.0.co;2-p
Subject(s) - cervical carcinoma , medicine , carcinoma , oncology , cervical cancer , cancer
There has been considerable debate regarding the existence of HPV‐negative cervical carcinoma. In this issue of the journal, using well‐controlled methodology, Walboomers et al . demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV‐negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening. Copyright © 1999 John Wiley & Sons, Ltd.